Heart disease remains the number-one cause of death worldwide. Each year, over 17 million people die from cardiovascular conditions.
New medications help control risk factors and save lives during heart attacks. However, full recovery of injured heart tissue is uncommon. As a result, survivors often progress to heart failure, a debilitating, progressive condition.
Stem cell therapy aims to regenerate damaged muscle through cell replacement and by boosting innate repair processes. Mesenchymal stem cells show particular promise for healing heart disease.
Mesenchymal stem cells possess a diverse toolkit that activates the heart’s innate capacity to fix itself.
MSCs secrete anti-inflammatory signals that switch off harmful immune reactions. They produce growth factors that inhibit cell death pathways and prevent scarring.
MSCs also spark division of resident heart stem cells while guiding their maturation into beating heart muscle cells called cardiomyocytes. However, the direct transformation of MSCs into cardiomyocytes appears modest.
Instead, MSCs heal through close communication with nearby cells. They transfer regenerative organelles and packets of genetic material to neighboring cells through tiny tunnels and extracellular bubbles. This horizontal transfer alters the function of recipient cells.
MSCs derived from different tissues have slightly different properties. For example, bone marrow MSCs specialize in quieting inflammation. In contrast, umbilical cord MSCs secrete abundant signals that stimulate new blood vessel and nerve growth.
Since heart disease involves both inflammatory and vascular components, combining umbilical and bone marrow MSC types could have synergistic benefits.
Furthermore, umbilical MSCs have particular advantages. They are more youthful with greater expansion and engraftment potential compared to adult MSCs from bone marrow or fat.
Unfortunately, reparative capacity declines as MSCs age. Fortunately, strategies exist to reverse aging. For example, boosting the protein SIRT3 reinvigorates aged MSCs.
Careful screening for fit young cell populations prior to patient administration ensures maximum treatment potency.
Extensive preclinical animal research supports using MSCs to treat injured heart muscle.
MSC injection into damaged areas reduces scar size by over 50% and significantly improves pumping capacity in animal models – from mice to pigs.
A meta-analysis of over 50 studies calculated a meaningful average 7.5% increase in heart ejection fraction with MSC therapy. Pigs receiving human umbilical cord blood MSCs showed similar large benefits.
Early phase clinical trials in heart failure patients echo these positive preclinical findings. Patients report feeling much better with substantially enhanced quality of life. Objective measures confirm significant increases in heart function.
The Stem Cell Medical Center provides cutting-edge stem cell solutions tailored to each patient’s unique needs. Their regenerative treatments stimulate the body’s innate ability to heal itself.
A combination master class utilizes both umbilical and bone marrow MSCs to maximize synergistic repair pathways. Careful screening ensures only young, vital cell populations get administered.
The medical team closely monitors each patient before, during, and after therapy to ensure excellent continuity of care. Their commitment to medical excellence makes the Stem Cell Center a top global destination for healing hearts.
If your heart needs healing, contact the Stem Cell Center today to learn how their regenerative treatments can help strengthen your engine and get you back on the road to health.
Contact us and schedule a consultation to see if you may benefit from regenerative treatments. Stem cell therapy could alleviate your pain and help you regain mobility.